Multiple Pathways of Spx (YjbD) Proteolysis in Bacillus subtilis
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چکیده
منابع مشابه
Multiple pathways of Spx (YjbD) proteolysis in Bacillus subtilis.
ATP-dependent proteases degrade denatured or misfolded proteins and are recruited for the controlled removal of proteins that block activation of regulatory pathways. Among the ATP-dependent proteases, those of the Clp family are particularly important for the growth and development of Bacillus subtilis. Proteolytic subunit ClpP, together with regulatory ATPase subunit ClpC or ClpX, is required...
متن کاملThe YjbH protein of Bacillus subtilis enhances ClpXP-catalyzed proteolysis of Spx.
The global transcriptional regulator Spx of Bacillus subtilis is controlled at several levels of the gene expression process. It is maintained at low concentrations during unperturbed growth by the ATP-dependent protease ClpXP. Under disulfide stress, Spx concentration increases due in part to a reduction in ClpXP-catalyzed proteolysis. Recent studies of Larsson and coworkers (Mol. Microbiol. 6...
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Entry into stationary phase in Bacillus subtilis is linked not only to a redirection of the gene expression program but also to posttranslational events such as protein degradation. Using 35S-labeled methionine pulse-chase labeling and two-dimensional polyacrylamide gel electrophoresis we monitored the intracellular proteolysis pattern during glucose starvation. Approximately 200 protein spots ...
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Goldman, Manuel (The University of Michigan, Ann Arbor) and Harold J. Blumenthal. Pathways of glucose catabolism in Bacillus subtilis. J. Bacteriol. 86:303-311. 1963.-Under aerobic conditions, resting cells of Bacillus subtilis Marburg C4 catabolized 60 to 70% of glucose by the Embden-Meyerhof pathway and the remainder by the hexose monophosphate pathway; under anaerobic conditions, the percent...
متن کاملLocalization of general and regulatory proteolysis in Bacillus subtilis cells
Protein degradation mediated by ATP-dependent proteases, such as Hsp100/Clp and related AAA+ proteins, plays an important role in cellular protein homeostasis, protein quality control and the regulation of, e.g. heat shock adaptation and other cellular differentiation processes. ClpCP with its adaptor proteins and other related proteases, such as ClpXP or ClpEP of Bacillus subtilis, are involve...
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ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 2002
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.184.13.3664-3670.2002